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Despite significant advances in reproductive medicine, embryo transfer (ET) does often not result in the desired pregnancy, which induces a significant psychological burden, results in a reduction in quality of life and the decision to prematurely stop fertility treatment. This qualitative study explores the emotional, psychological, and social impact of recurrent implantation failure (RIF) to provide a basis for better patient support and future research. Methods: The semistructured interview guide included 35 key questions developed on the basis of the available literature and clinical experience of specialists in fertility medicine. A convenience sample of women with at least three consecutive unsuccessful ETs was interviewed. Sample size was determined by achieving satiety, i.e. when no more new aspects were reported. This resulted in a total of 13 interviews, which were analyzed by qualitative content analysis. Continue reading